HORMONE BALANCING
ENDOCRINOLOGY
CCIM is a nationwide leader in endocrinology. We use blood, saliva, and urine (DUTCH) testing to comprehensively assess hormone levels. Dr DV is a member of the American Association of Clinical Endocrinologists, and has extensive experience treating medical conditions using hormone therapies.
Hormones are important molecules and compounds which facilitate communication between cells in the body, and tell DNA what to do. Impaired levels of hormones can be common causes of medical problems.
Dysbiotic gut inflammation from a damaged microbiome causes endocrine problems. The restoration of hormone balance while repairing the microbiome is our unique specialty.
https://ccimhealth.com/wp-content/uploads/2020/10/Endocrinology.mp4ALL OF THE FOLLOWING CONDITIONS ARE ENDOCRINE PROBLEMS THAT RESULT FROM DYSBIOTIC GUT INFLAMMATION:
HORMONE BALANCING
ENDOCRINOLOGY
CCIM is a nationwide leader in endocrinology.
We use blood, saliva, and urine (DUTCH) testing
to comprehensively assess hormone levels.
- Estrogen lowering aromatase inhibitors (anastrozole)
- Dihydrotestosterone (DHT) lowering 5-alpha reductase inhibitor treatments (finasteride)
ENDOCRINOLOGY
CORTISOL PHYSIOLOGY https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263906/
- 11 beta HSD1 - promotes conversion of inactive cortisone to cortisol, promotes Cushing-like fat redistribution, promotes weight gain, obesity, metabolic syn, glaucoma, bone resorption
- Chronic inflammation leads to damage to the cortisol receptor
- Chronic cortisol secretion leads to down-regulation / resistance of the cortisol receptor to cortisol binding
- Cortisol's job is to regulate the inflammatory response; cortisol dysfunction therefore leads tissues susceptible to intracellular and tissue degeneration / breakdown, celluar death and aging
- Cortisol dysfunction leads to chronic pain
- SALIVARY CORTISOL TESTING IS HIGHLY ACCURATE
- MORE SALIVARY CORTISOL STUDIES
- Chest. 2011;140(5):1216-1222
- Neuropsychobiology. 1989;22(3):150-69
- Exp Clin Endocrinol Diabetes 2005; 113(4): 225-230
- The British Journal of Psychiatry Jan 2004, 184 (2) 136-141
- Restoring normal cortisol function in adrenal insufficient patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475279/
Patterns of Salivary Estradiol and Progesterone across the Menstrual Cycle:
ESTROGEN
- Migraine & Estrogens
- Estrogen and vertigo
- Estrogen Dominant Physiology promotes autoimmunity:
- Estrogen and gut dysbiosis: Repair of the microbiome measurably improves estrogen-mediated illness
MISCELLANEOUS
- Tinnitus is associated with endocrine hypofunction: https://jamanetwork.com/journals/jama/article-abstract/261359
- About CLOMID: http://contemporaryobgyn.modernmedicine.com/contemporary-obgyn/news/clinical/clinical-pharmacology/clomiphene-citrate-use-ovulation-induction-wh?page=full
ANABOLICS / ANDROGENS
- Oxandrolone 20mg daily x 3mo -> ReMyelination, increase muscle generation, reinnervation of muscle https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629627/
PROGESTERONE
Progesterone treatment for migraine:
Progesterone to prevent and treat neuropathic pain:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020818/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085268/
- http://endocomprehensive.blogspot.com/2014/04/progesterone-and-nerve-pain.html
- https://www.researchgate.net/figure/Effect-of-progesterone-administration-on-neuropathic-pain-associated-behaviorsafter_fig1_51453432
Neuroregenerative effects of progesterone:
Progesterone for acne:
TESTOSTERONE
- Testosterone therapy does not increase cancer risk:
- Maca raises testosterone levels: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070333/
PREGNENOLONE
- https://www.grc.com/health/research/Pregnenolone/Pregnenolone.pdf
- for brain health and fatigue:
- https://pdfs.semanticscholar.org/5bcc/dc43155b0b14ef3da1c2dcc2a3751887665a.pdf
TBI & Endocrinology / Dr Mark Gordon:
Chronic pelvic pain syndrome and gut dybiosis
Endocrinopathy of CRPS in women:
Cortisol for chronic pain
- https://www.ncbi.nlm.nih.gov/pubmed/25827960
- http://www.journalofprolotherapy.com/pdfs/issue_08/issue_08_06_hormones_for_pain.pdf
- https://www.practicalpainmanagement.com/treatments/hormone-therapy/hormone-treatments-chronic-intractable-pain
- http://hormonesandpaincare.com/pages/wp-content/uploads/2016/11/Chp5-Normal_Hormone_Serum_Levels_Essential_for_Chronic_Pain_Management.pdf
LDN for chronic pain
AUTOIMMUNE DISEASE
Bioidentical Hormone treatments in women decrease inflammation, decrease vascular inflammation/heart attack and stroke risk, improve immune system function, decrease depression, relieve menopause symptoms, improves health outcomes based on this 3-year study:
https://www.ncbi.nlm.nih.gov/pubmed/23627249
And no side effects / blood clot / cancer risks were noted
Impaired estrogen signaling/metabolism is linked to autoimmune diseases
- https://www.sciencedaily.com/releases/2018/05/180531131116.htm
- https://www.frontiersin.org/articles/10.3389/fimmu.2018.02279/full
We address this by using progesterone and emphasizing a plant-based diet to optimize estrogen metabolism and signaling. Progesterone regulates the estrogen receptor, and a plant-based diet promotes optimal excretion of inflammatory estrogen metabolites.
Progesterone (and testosterone) suppresses autoimmune inflammation:
https://www.researchgate.net/publication/51919501_Progesterone_and_Autoimmune_Disease
https://www.ncbi.nlm.nih.gov/pubmed/7923746
PROGESTERONE FOR SCLERODERMA
- Fibroblasts are activated in scleroderma and create scar tissue in the lung in pulmonary scleroderma. Progesterone inhibits fibroblast activity https://www.karger.com/Article/PDF/233673
- T cell activation in scleroderma promotes inflammation; progesterone inhibits T cell activation https://www.nature.com/articles/mi201735
- Scleroderma is characterized by Th1 immune activation; progesterone inhibits this and promotes a Th2 immune activation
Testosterone for MS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724009/
PROSTATE
Microbiome & Prostate disease
https://www.ncbi.nlm.nih.gov/pubmed/29795140
https://www.ncbi.nlm.nih.gov/pubmed/31493090
Testosterone for prostate cancer patients:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647137/
- https://www.hopkinsmedicine.org/news/media/releases/surprise_high_dose_testosterone_therapy_helps_some_men_with_advanced_prostate_cancer
- https://pcri.org/insights-blog/2018/7/25/is-testosterone-the-new-therapy-for-prostate-cancer
CHRONIC PAIN:
LDN 3mg at night (provided by compounding pharmacist)
- https://www.ldnresearchtrust.org/content/low-dose-naltrexone-and-chronic-pain-pradeep-chopra-md
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/
- https://academic.oup.com/painmedicine/article-abstract/15/5/883/1812526?redirectedFrom=fulltext
Hormone Treatments: Cortisol, Pregnenolone, DHEA, Testosterone, Progesterone, IGF1
- Cortisol for pain in opioid patients: https://www.ncbi.nlm.nih.gov/pubmed/25827960
- http://www.journalofprolotherapy.com/pdfs/issue_08/issue_08_06_hormones_for_pain.pdf
- https://www.practicalpainmanagement.com/treatments/hormone-therapy/hormone-treatments-chronic-intractable-pain
- http://hormonesandpaincare.com/pages/wp-content/uploads/2016/11/Chp5-Normal_Hormone_Serum_Levels_Essential_for_Chronic_Pain_Management.pdf
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020818/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085268/ http://endocomprehensive.blogspot.com/2014/04/progesterone-and-nerve-pain.html
- https://www.researchgate.net/figure/Effect-of-progesterone-administration-on-neuropathic-pain-associated-behaviorsafter_fig1_51453432