DETOXIFICATION Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/ phase I cytochrome P450 redox & hydrolysis enzymes (CYP1A family) Enzymes involved:
- CYP1A1 enhances activity
- CYP1A2 inhibits activity
- CYP2A-E important for metabolizing medications and neurologic toxins, and is induced by quercetin, broccoli, chicory, rosemary, garlic, and inhibited by tea, cruciferous vegetables, NAC, dandelion, MCT, chrysin
- CYP3A enzymes are induced by rooibos, curcumin, garlic, fish oil, and inhibited by grapefruit, tea, quercetin, and is important for metabolizing hormones, aflatoxin B1. This family important for metabolizing 50% of all pharmaceuticals
Function:
- Phase 1 important for metabolizing carcinogens, xenobiotics, steroid hormones, hydrocarbons, PCBs, and pharmaceuticals, making them hydrophilic
Location:
- occurs in liver, intestine, kidney, lung, brain
Concerns:
- can lead to oxidative damage due to ROS buildup (so need antioxidants)
- low activity can increase cancer risk
Recommendations:
- I3C 500mg/day, resveratrol 1g/d, quercetin 500mg/d
- Consume: tea, polyphenols, rooibos tea, celery, cruciferous vegetables, fish oil, garlic, rosemary, astaxanthin, chickory, pomegranate, walnuts, algae, curcumin/turmeric, carrot, dill, parsley, shellfish
phase II conjugation enzymes Function: convert hydrophilic compounds to excretable salts in bile or urine Enzymatic activities:
- Glucuronidation- occurs in the liver and intestine; important for metabolizing medications. Induced by cruciferous vegetables, resveratrol, citrus, dandelion, rooibos tea, rosemary, soy, curcumin, astaxanthin. Glucuronic acid provided in bean sprouts, lentils, vegetables, fruits
- Beta-glucuronidase is a bacterial enzyme which can be inhibited by polyphenols and berries and is promoted by animal fat
- Sulfotransferases transfer a sulfuryl group to the substrate in the liver, intestine, adrenal, brain, skin.
- The decreased function can lead to hormone deficiencies. Important for eliminating toxic substrates.
- Induced by retinoic acid and caffeine, and inhibited by synthetic food dies, flavonoids, estrogens, B6
- Glutathione transferase adds glutathione to a metabolite (intrinsic antioxidant activity). Induced by cruciferous vegetables, garlic, resveratrol, fish oil, curcumin, rosemary, ghee
- Promoted by B6, magnesium, selenium, glycine, ALA, silymarin, artichoke, turmeric
- Amino acid transferase
- Adding amino acids to a substrate can promote excretion. AAs used include glycine, taurine, glutamine
- Acetylation
- Important for metabolizing aromatic hydrocarbons (pharmaceuticals). Enhanced by 500mg/day of quercetin
- Methylation
- SAMe provides a methionine group in a reaction catalyzed by methyltransferases (such as COMT- important for methylating estrogens).
- Suppressed by simple carbs
- Supported by Magnesium, SAMe, curcumin, Methyl B12, folic acid
Nrf2 signaling
- Protects against ROS- related conditions assoc with chronic inflammation
- Modulated by curcumin, broccoli, garlic, resveratrol, ginger, rosemary, pomegranate, astaxanthin
- When activated, NRF2 dissociates from cytosolic protein KEAP1, and moves to the nucleus to bind to AREs assoc with phase 2 detox and antioxidant enzyme genes
Metallothionein
- Cysteine-rich protein that binds divalent cations (heavy metals)
- Sequesters heavy metals, scavenges free radicals, inhibits NFKB
- Promoted by phytonutrient-rich diets, zinc, quercetin, cordyceps
DETOXIFICIATION
LOVING ENZYMES
The purpose of the integrative alchemy service is to offer proactive psychospiritual and experiential yogatherapeutic strategies to optimize alignment in every aspect of life.
DIAGNOSIS
Identifying the root cause.
TREATMENT
Custom tailored care.
REVERSAL
Beyond recovery, reversal.
